Complex PTSD (C-PTSD) is associated with reduced activity in the prefrontal cortex. Because this region supports higher-level cognition, attention, decision-making, and impulse control, its reduced activity is relevant to difficulties in these functions.

Wayne State University

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The significant loss of multiple brain regions results in a dramatic loss in brain functionality. Additionally, the heightened function of the amygdala and lack of function in the frontal lobe results in a major change in the behavior of C-PTSD patients. 

Functional changes C-PTSD patients as a result of volume loss

The hippocampal cortex is responsible for the regulation of our emotions, motivation, learning, and memory. Which explains many of the symptoms C-PTSD patients readily experience. The 

Functional changes in hippocampal cortex

The amygdala functions to regulate our fight or flight responses. In many C-PTSD patients, outbursts of fear and dissociation are heavily prevalent due to the hyperactivity of the amygdala.

Functional changes in the amygdala

The ACC is responsible in regulating empathy, decision making, impulse, and emotions. The loss in this region of the brain is what results in impulsive behavior and behavioral outbursts.

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