The primary signs and symptoms of Hansen's disease (leprosy) include skin lesions and a loss of pain sensation due to peripheral nerve damage, which increases vulnerability to secondary infections and physical injuries.

University of Wisconsin - Madison

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*Mycobacterium leprae* is a pathogenic species in the genus *Mycobacterium* that causes Hansen's disease (leprosy). It is covered by a waxy mycolic acid coat and is noted for causing a chronic infection that affects peripheral nerves and the mucosal surface of the respiratory tract.

*Mycobacterium leprae*

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Microbiology covers the scope and sequence requirements for a single-semester microbiology course for non-majors. The book presents the core concepts of microbiology with a focus on applications for careers in allied health. The pedagogical features of the text make the material interesting and accessible while maintaining the career-application focus and scientific rigor inherent in the subject matter. Microbiology’s art program enhances students’ understanding of concepts through clear and effective illustrations, diagrams, and photographs.

Microbiology is produced through a collaborative publishing agreement between OpenStax and the American Society for Microbiology Press. The book aligns with the curriculum guidelines of the American Society for Microbiology.

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Signs and Symptoms of Hansen's Disease (Leprosy)

The virulence factors of *Mycobacterium leprae* are the capsule and cell wall that allows this bacterium to invade other cells and destroy neurons. It is also able to resist reactive oxygen species that macrophages produce. 

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