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Steps of Influenza Infection

The replication cycle of the influenza virus consists of six stages:

  1. Attachment: The virus binds to receptors on a target epithelial cell.
  2. Penetration: The host cell engulfs the virus through endocytosis, enclosing it in a vacuole.
  3. Uncoating: The viral envelope and contents are released from the vacuole.
  4. Biosynthesis: The viral RNA enters the nucleus, where it is replicated by RNA polymerase.
  5. Assembly: New viral particles are assembled.
  6. Release: The newly formed viral particles exit into the extracellular fluid, leaving the host cell alive to continue virus production.
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Updated 2026-06-03

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